DLL4 HEK293
CBP74599
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| I. Background | |
| DLL4基因编码的Delta样蛋白4是Notch信号通路的关键配体之一。该蛋白顺利获得结合并激活Notch受体(尤其是Notch1和Notch4),在多种组织的发育,特别是胚胎期及成体的血管新生(Angiogenesis)中发挥核心调控作用。它顺利获得负反馈机制精细调节血管出芽和分支,对维持正常血管功能至关重要。DLL4在多种实体瘤中异常高表达,顺利获得促进肿瘤血管生成和维持肿瘤干细胞特性,成为抗癌药物开发的重要靶点。 | |
| II. Description | |
| DLL4 HEK293细胞,在 HEK293细胞的基础上,稳定表达 DLL4 。 | |
| III. Introduction | |
| Expressed gene: | DLL4 |
| Host Cell: | HEK293 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+2 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| IV. Representative Data | |
Figure 1. Recombinant DLL4 HEK293 constitutively expressing DLL4. |
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